RAP 86

1) Peds Septic Shock

Review Summary

  • Source: JAMA Network Open
  • Author: Matthew Eisenberg, MD
  • Reviewer: Thomas Meland, MD
5
/ 7
BEEM Rater Scale
3
/ 7
Educational Utility
3
/ 7
Evidence Based Medicine

Takeaway

In children without known cardiac dysfunction with septic shock, using norepinephrine as first line agent demonstrated a lower mortality and similar rates of kidney dysfunction when compared to epinephrine.

2) PEERLESS Trial

Review Summary

  • Source: First10EM
  • Author: Justin Morgenstern, MD
  • Reviewer: Michelle Nadrchal, MD
4
/ 7
BEEM Rater Scale
2
/ 7
Educational Utility
4
/ 7
Evidence Based Medicine

Takeaway

Interesting study to show non-inferiority, but limited application given no studies comparing these high-risk interventions to more standard options.

3) Vertigo Score (Review 1)

Review Summary

  • Source: EMA
  • Author: Mike Menchine, MD
  • Reviewer: Madie Vranyes, PA-C
3
/ 7
BEEM Rater Scale
2
/ 7
Educational Utility
3
/ 7
Evidence Based Medicine

Takeaway

The Sudbury Vertigo score cannot be used at the bedside yet as further prospective analysis will be necessary, but it does show promise as a tool for differentiating CNS causes of vertigo and benign causes.

4) Vertigo Score (Review 2)

Review Summary

  • Source: EMA
  • Author: Mike Menchine, MD
  • Reviewer: Alora Sager, MD
3
/ 7
BEEM Rater Scale
3
/ 7
Educational Utility
4
/ 7
Evidence Based Medicine

Takeaway

The Sudbury Vertigo Score performed well on validation testing with scores < 5 being associated with 0% risk of serious outcomes. This scoring system may be a useful clinical tool in the future.

5) Lifetime Cancer Risk from CTs

Review Summary

  • Source: JAMA
  • Author: Rebecca Smith-Blindman, MD, et al.
  • Reviewer: Kurt Isenberger, MD
4
/ 7
BEEM Rater Scale
3
/ 7
Educational Utility
4
/ 7
Evidence Based Medicine

Takeaway

No simple solution to balance risks to benefits of CT, incorporating diagnostic algorithms and offering alternative imaging modalities as alternative to ionizing radiation maybe beneficial.