RAP 60

1) Adverse Ischemic/Hemorrhagic Events with Rivaroxaban vs. Apixaban

Review Summary

  • Source: JAMA Network Open
  • Author: Wayne Ray, et al.
  • Reviewer: Sam Southgate, MD
4
/ 7
BEEM Rater Scale
3
/ 7
Educational Utility
6
/ 7
Evidence Based Medicine

Takeaway

Compared to apixaban, rivaroxaban was associated with higher risk of major hemorrhagic or ischemic events in this retrospective study

2) IV Magnesium for Asthma in Kids

Review Summary

  • Source: Journal Feed
  • Author: Clay Smith, MD
  • Reviewer: Alec Haug, MD
3
/ 7
BEEM Rater Scale
2
/ 7
Educational Utility
2
/ 7
Evidence Based Medicine

Takeaway

If an article is potentially practice-changing, read and try to understand the article. 

3) INTUBE Study: Adverse peri-intubation events in the critically ill

Review Summary

  • Source: Journal Feed
  • Author: Salim Rezaie, MD
  • Reviewer: Alex Buchholz, MD
3
/ 7
BEEM Rater Scale
3
/ 7
Educational Utility
5
/ 7
Evidence Based Medicine

Takeaway

Resuscitate before you intubate to avoid the most common peri-intubation adverse event: cardiovascular instability.

4) Adexanet Alfa vs. Four-Factor PCC

Review Summary

  • Source: REBEL EM
  • Author: Sarah Aly, DO
  • Reviewer: Caitlyn Brown, PharmD
3
/ 7
BEEM Rater Scale
3
/ 7
Educational Utility
5
/ 7
Evidence Based Medicine

Takeaway

In patients with ICH on factor-Xa inhibitors (n=44) there was no statistically significant difference in CT stability at 24 hours (88% AA v 60% 4FPCC). Larger studies are needed. 

5) Etomidate vs. Ketamine for Intubation

Review Summary

  • Source: The Skeptics’ Guide To EM
  • Authors: Ken Milne, MD, Missy Carter, PA-C
  • Reviewer: Joe Walter, MD
3
/ 7
BEEM Rater Scale
4
/ 7
Educational Utility
5
/ 7
Evidence Based Medicine

Takeaway

Both agents can be cautiously used in critically ill patients and may both contribute to serious complications.